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Intradermal skin test results correlate with atopy

April 1, 2011  |  John R. Cohn, MD, FACAAI, Patricia Padams, BSN, RN, and Jeremy Zwillenberg, BA


Intradermal skin testing (IDST) is performed by most allergists, but its value remains controversial. In most previous studies assessing the value of IDST, a positive result was based on a 5- to 6-mm wheal and erythema. While a subject's immediate reaction upon allergen...

A comparison of techniques for evaluating IgE-mediated allergies

April 1, 2011  |  John H. Boyles Jr., MD


Skin prick testing remains the most popular way to confirm an IgE-mediated allergic response. This study was performed to compare the accuracy and sensitivity of two skin testing modalities (serial endpoint titration and skin prick testing with 2 different in vitro assays.) In...

Allergic fungal sinusitis

March 1, 2011  |  Lester D.R. Thompson, MD

Sensitivity and specificity of rapid antigen detection testing for diagnosing pharyngitis in the emergency department

April 1, 2010  |  Sezgin Sarikaya, MD, Can Aktaş, MD, Didem Ay, MD, Asli Çetin, MD, and Ferudun Celikmen, MD


Acute pharyngitis in adults is primarily a viral infection; only about 10% of cases are of bacterial etiology. Most cases of bacterial pharyngitis are caused by group A beta-hemolytic streptococci (GABHS). One laboratory method for the diagnosis of GABHS is rapid antigen...

Impaired mucociliary clearance in allergic rhinitis patients is related to a predisposition to rhinosinusitis

April 1, 2009  |  Ioannis Vlastos, MD, Ioannis Athanasopoulos, MD, PhD, Nicholas S. Mastronikolis, MD, PhD, Theodora Panogeorgou, MD, Vassilios Margaritis, MD, Stefanos Naxakis, MD, PhD, and Panos D. Goumas, MD


Although mucociliary clearance has been shown to be impaired in patients with allergic rhinitis and chronic rhinosinusitis, its exact role in relation to a predisposition to rhinosinusitis is unknown. To investigate this possible association, we conducted a prospective study of...

Management of allergic fungal sinusitis with postoperative oral and nasal steroids: A controlled study

April 1, 2009  |  Mubasher Ikram, FCPS, Akbar Abbas, FCPS, Anwar Suhail, FRCS, Maisam Abbas Onali, MBBS, Shabbir Akhtar, FCPS, and Moghira Iqbal, FCPS


In patients with allergic fungal sinusitis, the mainstay of treatment remains surgical removal of allergic mucin and fungal debris. But as a single modality, surgery is associated with high rates of recurrence, so a number of adjunctive medical modalities have been tried,...

Effects of sequential Dermatophagoides pteronyssinus antigen stimulation on anatomy and physiology of the larynx

February 1, 2009  |  James P. Dworkin, PhD, Patrick M. Reidy, MD, Robert J. Stachler, MD, and John H. Krouse, MD, PhD


The goal of this investigation was to study the effects of sequential dust mite antigen stimulation on the appearance and function of the larynx. To that end, we designed a randomized, placebo-controlled, double-blind, prospective analysis of adults who had tested positive for...

Long-term immunotherapy for perennial allergic rhinitis: Relationship of specific IgG levels to skin-prick test results and clinical symptoms and signs

December 1, 2008  |  Rauf Tahamiler, MD, Salih Canakcioglu, MD, Suleyman Yilmaz, MD, and Huseyin Isildak, MD


We studied 63 adults with perennial allergic rhinitis and positive skin-prick tests for Dermatophagoides pteronyssinus (Dp) and Dermatophagoides farinae (Df) who had not previously received any type of immunotherapy or pharmacotherapy for their condition. We...

Prevalence of autoimmune thyroid disease in chronic rhinitis

September 1, 2008  |  William R. Reisacher, MD, FACS, FAAOA


A retrospective, controlled study was undertaken to determine the prevalence of autoimmune thyroid disease in 111 adult patients with allergic (77) and nonallergic (34) rhinitis seen in a private ENT/allergy practice in the lower Hudson Valley, New York. The control group...

Onset of action of ciclesonide once daily in the treatment of seasonal allergic rhinitis

June 1, 2008  |  Piyush Patel, MD, Deepen Patel, MD, Sudeesha Kunjibettu, PhD, Nancy Hall, MS, and Mark A. Wingertzahn, PhD


Ciclesonide is an intranasal corticosteroid approved for the treatment of allergic rhinitis. We conducted a randomized, double-blind, parallel-group, placebo-controlled study to evaluate the time to onset of action of ciclesonide 200 μg once daily in 502 adults with seasonal...

Efficacy comparison of multiple-antigen subcutaneous injection immunotherapy and multiple-antigen sublingual immunotherapy

August 1, 2007  |  Diego Saporta, MD, FACS, FAAOA; Alan B. McDaniel, MD, FACS, FAAOA
We performed an observational study to determine whether allergen-specific sublingual immunotherapy (SLIT) is as...

The effect of nasal steroid administration on intraocular pressure

July 1, 2007  |  Christos Spiliotopoulos, MD; Nicholas S. Mastronikolis, MD, PhD; Ioannis K. Petropoulos, MD; Ephigenia K. Mela, MD, PhD; Panos D. Goumas, MD, PhD; Sotirios P. Gartaganis, MD, PhD
The effect of systemic steroid administration on intraocular pressure (IOP) is well established. However, less...


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