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Carcinoma

Synchronous lesions of the right accessory parotid gland and left main parotid gland

June 20, 2017  |  Ba D. Nguyen, MD

Tumoral involvement of parotid glands is usually solitary; multifocality is rare

Parathyroid carcinoma in a patient with three prior parathyroid adenomas

June 20, 2017  |  Michael Goldenberg, MA; Henry Crist, MD; Darrin V. Bann, MD, PhD

Fine-needle aspiration is contraindicated because of its inability to distinguish parathyroid carcinoma from benign disease and the risk of seeding tumor along the biopsy tract.

Adenoid cystic carcinoma of the head and neck area: Oncologic treatment and plastic-reconstructive options

June 20, 2017  |  Johannes A. Veit, MD; Julia Thierauf, MD; Thomas K. Hoffmann, PhD, MD; Jens Greve, PhD, MD; Nicole Rotter, PhD, MD; Patrick J. Schuler, PhD, MD; Marc O. Scheithauer, PhD, MD

Abstract

Adenoid cystic carcinoma of the head and neck area is a rare malignant tumor with acceptable short-term but mediocre long-term prognosis. Radical tumor excision with clear resection margins, and sometimes resection of the facial nerve due to perineural growth, remains the...

Histologic correlation of VEGF and COX-2 expression with tumor size in squamous cell carcinoma of the larynx and hypopharynx

April 30, 2017  |  Rodrigo Gonzalez Bonhin, MD; Guilherme Machado de Carvalho, MD; Alexandre Caixeta Guimaraes, MD; Vanessa Brito Campoy Rocha, MD; Carlos Takahiro Chone, MD, PhD; Agrício Nubiato Crespo, MD, PhD; Eliane Maria Ingrid Amstalden, MD, PhD

Abstract

The prognosis and survival of patients with laryngeal and hypopharyngeal squamous cell carcinoma (SCC) are related to the clinical staging. Tumor growth and metastasis are closely related to angiogenesis. Vascular endothelial growth factor (VEGF) and cyclooxygenase 2 (COX-2)...

Breast cancer metastases to the head and neck: Case series and literature review

March 24, 2017  |  Jeremiah C. Tracy, MD; Nicholas R. Mildenhall, MD; Richard O. Wein, MD; Miriam A. O'Leary, MD

Abstract

Breast cancer is the most common cancer in women and is the second most common cause of cancer-related death. Despite the relatively high prevalence of this disease, breast cancer manifestations in the head and neck are relatively rare. Supraclavicular lymphadenopathy and bony...

Atypical parathyroid adenoma with diffuse fibrosis

February 20, 2017  |  Christine M. Clark, BA; Sakeena J. Payne, MD; Joshua I. Warrick, MD; David Goldenberg, MD, FACS

Atypical parathyroid adenomas are infrequently encountered and can present a diagnostic challenge, as they share overlapping clinical and histologic features with parathyroid carcinoma.

Locoregional control of tongue base adenoid cystic carcinoma with primary resection and radial forearm free flap reconstruction

January 25, 2017  |  Bharat B. Yarlagadda, MD; Josh C. Meier, MD; Derrick T. Lin, MD; Kevin S. Emerick, MD; Daniel G. Deschler, MD

Abstract

Adenoid cystic carcinoma of the minor salivary glands can be challenging and marked by high rates of local recurrence despite appropriate surgical resection. Management of this pathology in the base of the tongue is particularly difficult given the poor functional outcomes...

Secretory carcinoma

December 7, 2016  |  Lester D. Thompson, MD

This tumor presents as a solitary, circumscribed but not encapsulated mass, although it may have invasive borders.

End-of-life decision making in geriatric terminal head and neck cancer

December 7, 2016  |  Kourosh Parham, MD, PhD, FACS; Karen M. Kost, MD, FRCSC

In the oncogeriatric setting, the comprehensive geriatric assessment has been recognized as providing useful information supplementary to what can be obtained via standard oncology status assessments.

Risk of thyroid malignancy following an index head and neck squamous cell carcinoma: A population-based study

December 7, 2016  |  Jason Y. Chan, MBBS; Zhen Gooi, MBBS; Wojciech K. Mydlarz, MD; Nishant Agrawal, MD

Abstract

To evaluate the incidence of a subsequent primary thyroid malignancy in patients with an index head and neck squamous cell carcinoma (HNSCC), we analyzed the National Cancer Institute's Surveillance, Epidemiology, and End Results database to identify a cohort of patients who...

Cervical metastasis in squamous cell carcinoma of the hard palate and maxillary alveolus

October 25, 2016  |  Yekaterina Koshkareva, MD; Jeffrey C. Liu, MD; Miriam Lango, MD; Thomas Galloway, MD; John P. Gaughan, PhD; John A. Ridge, MD, PhD

Abstract

We conducted a retrospective study to determine the incidence and treatment outcomes of neck metastases in patients with squamous cell carcinoma (SCC) of the hard palate and/or maxillary alveolus after surgical excision of the primary tumor. We also sought to identify any risk...

Prognostic factors in metastatic cutaneous squamous cell carcinoma of the head and neck

October 25, 2016  |  Gideon Bachar, MD; Aviram Mizrachi, MD; Naomi Rabinovics, MD; Dan Guttman, MD; Thomas Shpitzer, MD; Dean Ad-El, MD; Tuvia Hadar, MD

Abstract

Metastatic cutaneous squamous cell carcinoma (SCC) of the head and neck poses a significant therapeutic challenge due to its aggressive biologic behavior. We conducted a retrospective study of 71 patients-58 men and 13 women, aged 28 to 88 years (mean: 71)-who had been treated...

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