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Managing head and neck malignancy arising in a field of Crohn disease inflammation: Report of a case

November 3, 2017  |  Christina Yver, MD, MBA; Darshana Jhala, MD; Amanda Muir, MD; Devraj Basu, MD, PhD

Abstract

Some of the clinical characteristics of Crohn disease of the head and neck overlap those of squamous cell carcinoma of the head and neck. We describe the diagnostic and therapeutic complexities we encountered in an unusual case of piriform sinus cancer that had arisen in a...

Nasal cavity tumefactive fibroinflammatory lesion mimicking recurrent mucoepidermoid carcinoma

August 24, 2017  |  Daniel Thomas Ginat, MD, MS; Elizabeth Blair, MD

The diagnostic imaging features of tumefactive fibroinflammatory lesions can mimic those of neoplasms.

Long-term recurrence-free survival after an unplanned reduction in radiotherapy for HPV-positive oropharyngeal SCC: Two cases and a review of the literature

July 18, 2017  |  Jason Liu, BS; David Goldenberg, MD; Salah Almokadem, MD; Henry Crist, MD; Heath B. Mackley, MD, FACRO

Abstract

There is currently no clear distinction between the treatment of HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma (OPSCC). HPV-positive OPSCC has been demonstrated to be more radiosensitive than its HPV-negative counterpart. Despite this, patients with HPV-...

Lymph-node-positive cutaneous nonmelanoma skin cancer: A poor-prognosis disease in need of treatment intensification

July 18, 2017  |  Lora S. Wang, MD; Elizabeth A. Handorf, PhD; John A. Ridge, MD, PhD; Barbara A. Burtness, MD; Miriam N. Lango, MD; Ranee Mehra, MD; Jeffrey C. Liu, MD; Thomas J. Galloway, MD

Abstract

Locoregionally advanced nonmelanoma skin cancer (NMSC) has an aggressive clinical course characterized by high rates of treatment failure and poor survival compared with localized skin cancers. Our goal was to investigate multimodal therapy for lymph-node-positive NMSC. Data...

Adenoid cystic carcinoma of the head and neck area: Oncologic treatment and plastic-reconstructive options

June 20, 2017  |  Johannes A. Veit, MD; Julia Thierauf, MD; Thomas K. Hoffmann, PhD, MD; Jens Greve, PhD, MD; Nicole Rotter, PhD, MD; Patrick J. Schuler, PhD, MD; Marc O. Scheithauer, PhD, MD

Abstract

Adenoid cystic carcinoma of the head and neck area is a rare malignant tumor with acceptable short-term but mediocre long-term prognosis. Radical tumor excision with clear resection margins, and sometimes resection of the facial nerve due to perineural growth, remains the...

Parathyroid carcinoma in a patient with three prior parathyroid adenomas

June 20, 2017  |  Michael Goldenberg, MA; Henry Crist, MD; Darrin V. Bann, MD, PhD

Fine-needle aspiration is contraindicated because of its inability to distinguish parathyroid carcinoma from benign disease and the risk of seeding tumor along the biopsy tract.

Synchronous lesions of the right accessory parotid gland and left main parotid gland

June 20, 2017  |  Ba D. Nguyen, MD

Tumoral involvement of parotid glands is usually solitary; multifocality is rare

Histologic correlation of VEGF and COX-2 expression with tumor size in squamous cell carcinoma of the larynx and hypopharynx

April 30, 2017  |  Rodrigo Gonzalez Bonhin, MD; Guilherme Machado de Carvalho, MD; Alexandre Caixeta Guimaraes, MD; Vanessa Brito Campoy Rocha, MD; Carlos Takahiro Chone, MD, PhD; Agrício Nubiato Crespo, MD, PhD; Eliane Maria Ingrid Amstalden, MD, PhD

Abstract

The prognosis and survival of patients with laryngeal and hypopharyngeal squamous cell carcinoma (SCC) are related to the clinical staging. Tumor growth and metastasis are closely related to angiogenesis. Vascular endothelial growth factor (VEGF) and cyclooxygenase 2 (COX-2)...

Breast cancer metastases to the head and neck: Case series and literature review

March 24, 2017  |  Jeremiah C. Tracy, MD; Nicholas R. Mildenhall, MD; Richard O. Wein, MD; Miriam A. O'Leary, MD

Abstract

Breast cancer is the most common cancer in women and is the second most common cause of cancer-related death. Despite the relatively high prevalence of this disease, breast cancer manifestations in the head and neck are relatively rare. Supraclavicular lymphadenopathy and bony...

Atypical parathyroid adenoma with diffuse fibrosis

February 20, 2017  |  Christine M. Clark, BA; Sakeena J. Payne, MD; Joshua I. Warrick, MD; David Goldenberg, MD, FACS

Atypical parathyroid adenomas are infrequently encountered and can present a diagnostic challenge, as they share overlapping clinical and histologic features with parathyroid carcinoma.

Locoregional control of tongue base adenoid cystic carcinoma with primary resection and radial forearm free flap reconstruction

January 25, 2017  |  Bharat B. Yarlagadda, MD; Josh C. Meier, MD; Derrick T. Lin, MD; Kevin S. Emerick, MD; Daniel G. Deschler, MD

Abstract

Adenoid cystic carcinoma of the minor salivary glands can be challenging and marked by high rates of local recurrence despite appropriate surgical resection. Management of this pathology in the base of the tongue is particularly difficult given the poor functional outcomes...

End-of-life decision making in geriatric terminal head and neck cancer

December 7, 2016  |  Kourosh Parham, MD, PhD, FACS; Karen M. Kost, MD, FRCSC

In the oncogeriatric setting, the comprehensive geriatric assessment has been recognized as providing useful information supplementary to what can be obtained via standard oncology status assessments.

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