IgG4-related plasma cell granuloma of the maxillary sinus: A report of 2 cases | Ear, Nose & Throat Journal Skip to content Skip to navigation

IgG4-related plasma cell granuloma of the maxillary sinus: A report of 2 cases

| Reprints
September 21, 2015
by Masaru Kojima, MD, PhD; Yoshimasa Nakazato, MD, PhD; Kaoru Hirabayashi, MD, PhD; Nobuhide Masawa, MD, PhD; Naoya Nakamura, MD, PhD

Abstract

We report 2 rare cases of IgG4-related plasma cell granuloma of the maxillary sinus. Histologically, both lesions were characterized by severe lymphoplasmacytic infiltration. In 1 case, fibrous sclerosis and obliterative arteritis were observed. Immunohistochemical study demonstrated that IgG4-positive cells comprised more than 40% of the IgG-positive plasma cells. Moreover, the serum IgG4 level was elevated in both cases. A good responsiveness to steroid therapy has been seen in IgG4-related disease. From a therapeutic perspective, it is important to recognize IgG4-related plasma cell granuloma.

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