Our objectives were to review our experience with laser- assisted diverticulotomy (LAD) in the treatment of Zenker diverticulum (ZD) and compare our results with those in published literature on other endoscopic and surgical techniques. We conducted a retrospective chart review of 57 patients who underwent LAD treatment of ZD in a single tertiary care institution. Data on surgical complications, length of stay, and follow-up were collected. Age ranged from 56 to 89 years. Endoscopic exposure of the diverticulum was not possible in 2 patients. All 55 remaining patients who underwent LAD had significant symptom improvement. Three patients developed complications (5.5%); 2 had cervical emphysemas that were managed conservatively, and 1 experienced postoperative bleeding that required return to the operating room. Mean follow-up was 16 months. Two patients (3.6%) required revision surgery at 1 year postoperatively. There were no mortalities associated with the surgery. LAD remains a safe and effective method for treating ZD. The procedure permits short hospital stays and prompt return to normal oral intake. Results are like those of previously published reports on the endoscopic staple diverticulotomy technique.