Acute ototoxicity from a single infusion of oxaliplatin | Ear, Nose & Throat Journal Skip to content Skip to navigation

Acute ototoxicity from a single infusion of oxaliplatin

| Reprints
June 1, 2010
by Narinder K. Malhotra, MD, Rizwan Aslam, DO, Sydney P. Lipman, MD, and Vicki J. Bilski, MS, CCC-A


Ototoxicity secondary to the administration of the chemotherapeutic agent oxaliplatin is uncommon. We report a case of unilateral hearing loss that occurred immediately after the infusion of a single dose of oxaliplatin in a 70-year-old woman who was undergoing postoperative chemotherapy for rectal adenocarcinoma. To the best of our knowledge, no such case has been previously reported in the literature. The hearing loss in our patient was severe enough to limit her daily activities, and she experienced only minimal improvement during the next 2 years of follow-up.

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