New Tx for Barrett's esophagus and esophageal dysplasia

October 12, 2010
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Constantine Frantzides MD, PhD, FACS, director of the Chicago Institute of Minimally Invasive Surgery, staff surgeon, and director of the Laparoscopic Fellowship Program at Saint Francis Hospital in Evanston, Ill., has pioneered a minimally invasive surgical technique for the treatment of Barrett's esophagus and high-grade esophageal dysplasia.

The technique, called Laparoscopic Transgastric Esophageal Mucosal Resection, or the Frantzides Technique, involves "stripping" esophageal mucosa that carries a precancerous lesion. This technique offers patients an alternative to traditional surgery, which removes the esophagus entirely, or to endoscopic procedures that examine and remove abnormal segments of the esophageal mucosa but may miss an underlying malignancy.

Dr. Frantzides and his colleagues reported the minimally-invasive technique and the outcomes in the

American Journal of Surgery (Am J Surg 2010 Aug;200[2]:305-7). Patients were followed for 4 to 7 years and did not experience a recurrence of dysplasia.




Patients who are candidates for this surgery include individuals who have precancerous Barrett's esophagus with high-grade dysplasia that results from gastroesophageal reflux disease (GERD). The Frantzides Technique can also be combined with an antireflux procedure to prevent GERD.