Tumor

Giant cell tumor of the larynx: A case of malignant sarcomatous transformation

June 11, 2013     Richard J. Vivero, MD; Sandeep P. Dave, MD; Carmen R. Gomez, MD; and Donald T. Weed, MD
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Abstract

We report what is to the best of our knowledge the first case of malignant transformation of a giant cell tumor of the larynx. The patient, a 34-year-old man, presented to our tertiary care university teaching hospital where he underwent hemilaryngopharyngectomy with radial forearm free flap reconstruction and 11 of 15 cycles of chemotherapy. He remained disease-free at approximately 6 years and 4 months of follow-up. The patient is decannulated and continues to have a good voice with excellent quality of life to this day. We discuss the patient's clinical course and subsequent treatment within the context of a review of the current literature regarding this disease entity. Our experience demonstrates that giant cell tumor of the larynx may present as a malignant neoplasm without adversely affecting the patient's prognosis when treated aggressively with surgical resection and adjunct chemotherapy.

Previous presentation: The information in this article has been updated from its original presentation as a poster at The Triologic Society's Combined Southern and Middle Sections Meeting; January 8-11, 2009; Bonita Springs, Fla.

Solitary extramedullary plasmacytoma of the nasal tract: An unusual cause of epistaxis

June 11, 2013     Kushaljit Singh Sodhi, MD, MAMS, FICR; Niranjan Khandelwal, MD, DipNB, FICR; Vivek Virmani, MD, DipNB, FRCR; Ashim Das, MD; and Naresh Panda, MS
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Abstract

Solitary extramedullary plasmacytoma is a rare hematologic malignancy with nonspecific clinical symptoms and imaging findings. We present a case of this entity that arose in the nasal tract of a 50-year-old man. The tumor was removed surgically, and the patient showed no evidence of recurrence on follow-up. We review the clinical features, imaging and histopathologic findings, and treatment of this rare disease. It is essential for otolaryngologists and head and neck surgeons to be familiar with this entity because total excision and radiation therapy for plasmacytomas can be curative in patients who have no underlying overt plasma cell dyscrasias.

Huge hibernoma of the neck with extension into the mediastinum

April 17, 2013     Ramanuj Sinha, MS, DNB; Saumik Das, MS, DNB; Pranabashish Banerjee, MS, MRCS; Atish Halder, DLO, MS; Mainak Dutta, MS
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Abstract

Hibernomas are benign tumors made up of brown fat. They are rarely encountered in otolaryngologic clinical practice, as they are usually located in the interscapular area, axilla, thigh, mediastinum, and retroperitoneum. We report an extremely rare case of a very large hibernoma in a 45-year-old man who presented with a 4-year history of neck swelling. Radioimaging was suggestive of a mass in both parapharyngeal spaces; the lesion was more prominent on the left side. The mass extended from C2 into the retropharyngeal space and superior mediastinum. Fine-needle aspiration cytology failed to yield a diagnosis. On surgical exploration, a tumor measuring 17 x 16 x 5 cm was removed and sent for histopathologic examination. Light microscopy was suggestive of a hibernoma. Staining with oil red O confirmed the diagnosis. To the best of our knowledge, a large hibernoma with such massive extension has not been previously reported in the literature.

Glomangioma of the nasal septum: A case report and review

April 17, 2013     Magdalena Chirila, MD, PhD; Liliana Rogojan, MD
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Abstract

Glomangioma is a painful, blue-red tumor that appears as a solitary encapsulated nodular mass, almost always on the skin. The first case of nasal glomangioma was reported in 1965. Since then, only 31 other cases have been reported in the literature. We present a new case of glomangioma of the nasal septum in a 61-year-old woman. The tumor was removed via an intranasal endoscopic excision. No recurrence was found at 3 years of follow-up. Our challenge was to distinguish the glomangioma from a true hemangiopericytoma and a paraganglioma.

Giant osteoma of the middle turbinate: A case report

April 17, 2013     Samar Pal Singh Yadav, MS(ORL); Joginder Singh Gulia, MS(ORL); Anita Hooda, MDS(Prosthodontics); Ajoy Kumar Khaowas, MS
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Abstract

Osteoma of the nose is a slowly developing benign tumor with a reported incidence of 0.6% of all the osteomas of the nose and paranasal sinuses. It is asymptomatic in initial stages and is usually diagnosed when it causes nasal obstruction. Osteoma arising from the middle turbinate is very rare and only two cases have been previously reported. We report a giant middle turbinate measuring 36 x 35 x 20 mm which, to the best of our knowledge, is the largest reported osteoma arising from the middle turbinate.

A case of glomangiopericytoma involving the orbital wall

April 17, 2013     Eun Sun Jung, MD, PhD; Suk-Woo Yang, MD, PhD; Ji-Hong Kim, MD; Soo Whan Kim, MD, PhD
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Abstract

Sinonasal type hemangiopericytomas are very rare tumors, and are often called glomangiopericytoma. They are believed to be derived from perivascular modified smooth muscle cells. Their origin is similar to glomus tumors but some distinct differences exist. Glomangiopericytomas are indolent tumors and overall survival rates are higher after complete surgical excision. Recurrence rates are as high as 30%. We present a case of glomangiopericytoma which involves the orbital wall, noteworthy because such bone-dissolving glomangiopericytomas are extremely rare.

Giant jugular foramen tumor

April 17, 2013     Wen-Sen Lai, MD; Jih-Chin Lee, MD; Chih-Hung Wang, MD, PhD; Yueng-Hsiang Chu, MD, PhD
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Jugular foramen syndrome is characterized by unilateral paralysis of the glossopharyngeal, vagus, and accessory nerves, which emerge in a line from the medulla oblongata and then run at the lateral part of the jugular foramen, where they leave the posterior cranial fossa.

Endolymphatic sac tumor

April 17, 2013     Lester D.R. Thompson, MD
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Oncocytoma of the nasal cavity: A case report

March 24, 2013     Mark E. Fons, DO; David Poetker, MD; Paul E. Wakely Jr., MD
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Abstract

Oncocytomas arising in the nasal cavity are quite rare. These entities more commonly occur in the major salivary glands, minor salivary glands, respiratory seromucinous glands, and endocrine organs. Very few cases of oncocytoma in the nasal cavity have been reported, with only 5 diagnosed as malignant. This article describes a case involving an 81-year-old man with a nasal oncocytoma that was completely resected with an endoscopic medial maxillectomy. The diagnostic rationale is discussed, along with a review of the literature.

Mastoid osteoma: A case report and review of the literature

March 24, 2013     Jeffrey Cheng, MD; Roberto Garcia, MD; Eric Smouha, MD
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Abstract

We describe the case of a 22-year-old woman who presented with a slowly growing osseous lesion of the mastoid cortex. On computed tomography, the lesion was found to involve the mastoid cortex, with which it demonstrated similar attenuation. The indications for treatment in this case were the patient's sensation of a mass effect, the encroachment of the mass onto the external auditory meatus, and a cosmetic deformity. The tumor was removed in its entirety via a postauricular approach. Findings on histopathologic examination were consistent with a compact osteoma. Mastoid osteomas are rare, benign tumors. If their growth significantly occludes the meatus, they may cause cosmetic deformities, conductive hearing loss, and recurrent external ear infections. Several other osseous lesions of the temporal bone should be considered in the differential diagnosis. The etiology of mastoid osteomas is poorly understood. Surgical management can be undertaken with minimal postoperative morbidity.

Malignant paraganglioma of the thyroid gland with synchronous bilateral carotid body tumors

February 25, 2013     Nadia Mohyuddin, MD; Karen Ferrer, MD; Urjeet Patel, MD, FACS
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Abstract

We describe a case of primary malignant paraganglioma of the thyroid gland that was found in a 55-year-old woman who had undergone surgery for bilateral carotid body tumors. The paraganglioma was treated with a total thyroidectomy followed by radiation therapy, and the patient was disease-free after more than 2 years of follow-up. Malignant paragangliomas of the thyroid gland are extremely rare. The diagnosis of malignancy is based on histopathologic findings, tumor behavior, and metastasis. These tumors can be misdiagnosed as other types of thyroid malignancies, thus resulting in less than optimal treatment. A genetic etiology was suspected in our patient.

Recurrent Pindborg tumor of the maxilla: A case report and review of the literature

February 25, 2013     Gangadhara Somayaji, MS(ENT); Aroor Rajeshwary, MS(ENT); Sullia Ramesh, MDS; Sullia Dinesh, MDS
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Abstract

We report a case of recurrent Pindborg tumor (calcifying epithelial odontogenic tumor) of the maxilla. The patient was a 34-year-old woman who had been previously diagnosed with Pindborg tumor and treated with curettage. She was subsequently referred to us for evaluation of nasal obstruction. Examination revealed the presence of a mass lesion in the right nasal cavity and right maxilla, which was identified as a recurrence of her earlier Pindborg tumor. The patient was treated with maxillectomy with orbital preservation. Pindborg tumor is a rare odontogenic tumor; when it does occur, it is more often seen in the mandible than in the maxilla. While this tumor is often treated with curettage alone, the aggressive nature of the recurrence in our patient necessitated radical surgery. We report this case to highlight the need to be suitably aggressive in treating these types of tumors in order to avoid recurrence.

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