Sarcoma

Leiomyosarcoma of the larynx: Case report and review of the literature

April 30, 2008     Jayant Sastri Goda, MD, DNB, Karuppiah Saravanan, MS, DNB, R.K. Vashistha, MD, FRCPath, Vinay Kumar, MD, and Ashok K. Gupta, MS
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Abstract

Leiomyosarcoma of the larynx is an extremely rare entity. This tumor is aggressive and is associated with dismal treatment results. We present a case of leiomyosarcoma of the larynx treated with surgery and postoperative radiotherapy. In this article we also discuss laryngeal leiomyosarcoma's clinical manifestations, associated diagnostic dilemmas, and optimal management, as well as a review of the literature.

Chondrosarcoma of the arytenoid cartilage: A case report and review of the literature

December 1, 2007     Stella Lee, MD, Anthony Sparano, MD, Paul Zhang, MD, and Natasha Mirza, MD
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Abstract

We report the case of a 56-year-old black woman with a locally aggressive chondrosarcoma at an unusual tumor site: the right arytenoid cartilage. The tumor extended from the superior pole of the right arytenoid cartilage to the soft-tissue areas of the right aryepiglottic fold, piriform sinus, and interarytenoid area. We undertook a conservative surgical approach by performing an endoscopic transoral CO2 laser resection, a right arytenoidectomy with wide soft-tissue margins, and a tracheotomy in anticipation of postoperative edema. Surgical exploration revealed that the tumor extended into the cricoid cartilage. Histopathology demonstrated a low-grade chondrosarcoma of the conventional variant. Clear margins were obtained by staged procedures. Chondrosarcomas of the larynx typically exhibit low-grade histopathology, and affected patients have a low incidence of metastasis and a good prognosis. Even so, these tumors can present diagnostic and therapeutic challenges. Surgical resection provides adequate airway protection and sound oncologic safety while preserving speech and swallowing, and these should be the surgeon's goals in this setting. Options include open laryngofissure, thyrotomy, organ preservation with partial laryngectomy, and endoscopic laser resection.

Radiation-induced osteosarcoma of the maxillary sinus

May 31, 2007     Sofia Avitia, MD; Ryan F. Osborne, MD, FACS
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Embryonal rhabdomyosarcoma of the temporal bone

March 31, 2007     Borlingegowda Viswanatha, MS, DLO
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Follicular dendritic cell sarcoma of the tonsil: A case report and literature review

March 31, 2007     Chad McDuffie, MD; Timothy S. Lian, MD; Joel Thibodeaux, MD
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Ewing sarcoma and primitive neuroectodermal tumor

February 1, 2007     Lester D.R. Thompson, MD, FASCP
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Supracricoid partial laryngectomy as a primary treatment for carcinosarcoma of the larynx

April 30, 2006     Kuauhyama Luna-Ortiz, MD; Adalberto Mosqueda-Taylor, DDS, MSc
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Abstract
Carcinosarcoma of the larynx is uncommon. When it does occur, its clinical features resemble those of sarcomatoid carcinoma, and its biologic behavior is similar to that of malignant mesenchymal neoplasms. We describe 2 cases of carcinosarcoma of the glottis. The tumors were staged as T3N0M0 and T2N0M0. Both patients were treated with supracricoid partial laryngectomy with cricohyoidoepiglottopexy. Eight months postoperatively, 1 of the 2 patients experienced a recurrence of the sarcomatous component of the tumor, and he underwent a total laryngectomy. The other patient remained free of disease at 12 months of follow-up. We conclude that supracricoid partial laryngectomy may be offered as an organ-preserving measure even in patients with sarcomatous disease; total laryngectomy can be held in reserve as a rescue measure. Patients must be closely monitored for early detection of recurrence. The role of adjuvant therapy for sarcomatous neoplasms in this area has not yet been clearly established.

Vocal fold atrophy after resection of a parapharyngeal space sarcoma

April 1, 2006     Libby J. Smith, DO; Mary Hawkshaw, RN, BSN; Robert T. Sataloff, MD, DMA
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Lower-extremity liposarcoma metastatic to the larynx: Case report

March 1, 2006     Scott F. Daly, MD; James Sciubba, DMD, PhD; Ralph P. Tufano, MD
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Abstract
Distant metastases to the larynx are rare. We describe the case of a 46-year-old man who was referred to our head and neck surgery clinic with a 6-week history of sore throat and otalgia. He was found to have a laryngeal lesion that was consistent with a primary myxoid liposarcoma that had been extirpated from a lower extremity earlier. To the best of our knowledge, no case of myxoid liposarcoma metastatic to the larynx has been previously reported in the English-language literature.

Rhabdomyosarcoma of the middle ear and mastoid: A case report and review of the literature

December 1, 2005     Akbar Abbas, FCPS; Sohail Awan, FCPS
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Abstract
We report a case of rhabdomyosarcoma of the middle ear and mastoid in a 3-year-old boy. The patient was treated according to Intergroup Rhabdomyosarcoma Study IV protocol (chemo- and radiotherapy), and he experienced a complete remission. However, 7 months after the completion of treatment, he experienced a recurrence at the primary site that spread to the brain. Despite treatment, the patient died of progressive metastasis to the lung 4 months later.

Primary carcinosarcoma of the helix of the ear

November 1, 2005     Vladimir Vincek, MD, PhD; Marjan Mirzabeigi, MD; Brian S. Jewett, MD; W. Jarrard Goodwin, MD
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Abstract
We report our histologic and immunohistochemical findings in a rare case of cutaneous carcinosarcoma involving the helix of the ear. The tumor exhibited cellular features of both basal cell and squamous cell carcinoma and a malignant mesenchymal component that was consistent with malignant fibrous histiocytoma. The epithelial component exhibited a positive immunohistochemical reaction to cytokeratin and a negative reaction to vimentin, whereas the mesenchymal component showed a positive immunohistochemical reaction to vimentin and a negative reaction to cytokeratin. To the best of our knowledge, this is only the third reported case of a carcinosarcoma of the ear and the second case in which it developed on the helix.

Dedifferentiated cervical liposarcoma

November 1, 2005     Jason Hamilton, MD; Sofia Avitia, MD; Ryan Osborne, MD; Jimmy Brown, MD, DDS
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