Neurofibroma

Plexiform schwannoma of the posterior pharyngeal wall in a patient with neurofibromatosis 2

March 2, 2015     Luca Raimondo, MD; Massimiliano Garzaro, MD; Jasenka Mazibrada, MD, PhD; Giancarlo Pecorari, MD; Carlo Giordano, MD
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Abstract

We report a case of plexiform schwannoma of the posterior pharyngeal wall that occurred in a 37-year-old man who had been previously diagnosed with neurofibromatosis type 2 (NF2). Plexiform schwannoma has been rarely reported in association with NF2. Moreover, as far as we know, only 6 cases of posterior pharyngeal wall schwannoma have been previously reported in the literature, none of which was associated with NF2 and none of which was histopathologically differentiated in schwannoma or plexiform schwannoma. The patient was treated with laser excision of the tumor via a transoral route, and at 6 and 12 months of follow-up, he exhibited no signs of recurrence. To the best of our knowledge, our patient represents the first reported case of a posterior pharyngeal wall schwannoma that occurred in association with NF2 and the first case in which the schwannoma was removed via transoral laser excision. This case illustrates that plexiform schwannoma is a possible finding in NF2 and that transoral laser excision is a safe surgical procedure in such a case.

Retropharyngeal masses in neurofibromatosis type 1: Imaging findings in 2 cases

December 19, 2014     Roy Riascos, MD; Jennifer Dodds, MD; Nirav Patel, MD
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Neurofibromatosis type 1 (NF-1) affects mesenchymal development via multisystemic manifestations. We present 2 cases of NF-1 that manifested as a retropharyngeal mass-1 as a lateral cervical meningocele in a 60-year-old man and the other as a focal neurofibroma in a 37-year-old man. Contrast-enhanced magnetic resonance imaging (MRI) was invaluable in identifying the exact nature of the 2 lesions; no contrast enhancement was seen in the case of the meningocele, and enhancement was seen in the case of the neurofibroma. These 2 cases illustrate the importance of the history and contrast-enhanced MRI in managing NF-1 patients with a retropharyngeal mass.

Transoral removal of a large parapharyngeal space neurofibroma with the Harmonic Scalpel

July 13, 2014     Marcel Marjanovic Kavanagh, MD; Zlatko Sabol, MD, PhD, MSc; Sasa Janjanin, MD, PhD; Drago Prgomet, MD, PhD
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Abstract

We report the case of a 19-year-old man with neurofibromatosis type 1 who presented for evaluation of odynophagia, left-sided hemiparesis, multiple café au lait spots all over his body, and numerous subcutaneous and cutaneous neurofibromas. Imaging revealed the presence of two large neurofibromas-a 60 x 50 x 35-mm tumor in the left parapharyngeal space and an intradural tumor measuring 25 mm in diameter. We removed the larger tumor via a transoral route with the Harmonic Scalpel. The size of this tumor far exceeded the size of any other reported tumor removed in this manner. Various approaches to the parapharyngeal space have been described in the literature. To the best of our knowledge, this case represents the first report of a transoral removal of a huge parapharyngeal space neurofibroma with a Harmonic Scalpel.

Intraparotid neurofibromatosis presenting with multiple nodules

June 11, 2013     Ryan F. Osborne, MD, FACS; Jason S. Hamilton, MD, FACS; and Reena Gupta, MD, FACS
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Often asymptomatic initially, neurofibromas may cause pain, weakness, and numbness as they grow as a result of compression of the underlying nerve fascicles.

Laryngeal plexiform neurofibroma in a child

June 11, 2013     Fikret Kasapoglu, MD; Talip Ozdemircan, MD; and Levent Erisen, MD
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Abstract

Neurofibromatosis (NF) is a genetically inherited, autosomal dominant disease, characterized by multiple cafe au lait spots, cutaneous neurofibromas and “Lisch nodules.” Neurofibromatosis can develop from a neural source at any age. However, neurofibroma of the larynx is extremely rare and is usually manifested by obstructive airway symptoms. We encountered a 5-year-old child presenting with stridor and dyspnea, who had a diagnosis of laryngeal plexiform neurofibroma. The purpose of our report is the consideration of laryngeal NF in the differential diagnosis of dyspnea in infants and children.

Intraparotid neurofibromatosis

June 4, 2012     Ryan F. Osborne, MD, FACS; Jason S. Hamilton, MD, FACS; Reena Gupta, MD, FACS
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Neurofibromas, which occur in the peripheral nervous system, frequently begin asymptomatically, but as they grow and compress underlying nerve fascicles, they can cause pain, weakness, and numbness.

Isolated neurofibroma of the tongue presenting as a papilloangiomatous mass

February 1, 2011     Mainak Dutta, MBBS and Soumya Ghatak, MS

Bilateral solitary maxillary sinus neurofibroma

January 1, 2010     Deb Biswas, MS (ORL), MRCS (Edinburgh), DOHNS (Eng) and Ranjit Mal, FRCS
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Abstract

We present a case of simultaneous bilateral neurofibroma of the maxillary sinuses. To the best of our knowledge, this is the first reported case of solitary neurofibromas arising from maxillary antra bilaterally and independently.

Neurofibromatosis type 1 causing conductive hearing loss

April 30, 2009     Thabet Abbarah, MD, FACS and M. Aiman Abbarah, MD

Solitary neurofibroma of the palatine tonsil: A case report

December 1, 2007     Kumar Madhumita, MS(ENT), Ajit Nambiar, MD(Path), and Parameswaran Prathapan, MS(ENT)
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Abstract

We present a rare case of a benign tumor of the tonsil in a 49-year-old woman. The tumor was excised in its entirety, and the patient's postoperative course was uneventful. No evidence of recurrence was detected during follow-up. Although some sporadic cases of tonsillar schwannoma have been reported, to the best of our knowledge this is only the second case of a solitary neurofibroma of the palatine tonsil to be reported in the English-language literature.

Neurofibroma of the pinna

January 1, 2007     Azhar M. Shaida, MA, FRCS; Matthew W. Yung, PhD, FRCS
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