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A case of radiation-induced mucosal melanoma in an immunohistochemically S-100-negative patient

August 21, 2016  |  Michael Rodriguez, DO; Yash Patil, MD; Arun Gupta, DO, MPH


We report a case of radiation-induced mucosal melanoma in a 41-year-old woman with a history of childhood rhabdomyosarcoma of the nasal cavity that had been treated with radiotherapy. During the workup for the melanoma, the patient was found to be negative for S-100 protein on...

Primary melanoma of the petrous temporal bone

July 21, 2015  |  Jonathan L. McJunkin, MD; Richard J. Wiet, MD, FACS


Melanoma is a malignant tumor of melanocytes that is predominantly found in the skin. In rare cases, it arises from mucosal melanocytes. We describe a case of a solitary melanoma of the petrous apex of the temporal bone in a 67-year-old woman who presented with sudden hearing...

Cutaneous malignant melanoma metastatic to the sphenoid sinus

December 19, 2014  |  Silviu Albu, MD; Opincariu Iulian, MD; Sorin Necula, MD

While metastases to the paranasal sinuses are unusual, metastases to the sphenoid sinus are exceedingly rare, especially metastases of a cutaneous melanoma to the mucosa. We report the case of a 38-year-old man who presented with a solitary sphenoid sinus metastasis that had spread from a...

Primary malignant melanoma of the external auditory canal extending into the preauricular area and scalp

October 18, 2014  |  Mainak Dutta, MS; Soumya Ghatak, MS; Ramanuj Sinha, MS, DNB


Malignant melanomas in the head and neck region are uncommon. When they do occur, they usually represent a metastasis. To the best of our knowledge, only 11 cases of primary malignant melanoma of the external auditory canal have been previously reported in the English-language...

Sinonasal tract mucosal melanoma

October 18, 2014  |  Lester D.R. Thompson, MD

Patients with obstructive symptoms, multiple sites of involvement, tumors of 3 cm or larger, an undifferentiated tumor on histology, a high mitotic count, and an elevated stage are more likely to have a poor prognosis.

A study of mucosal melanoma of the oral cavity in India: A rare tumor

August 28, 2014  |  Pankaj Chaturvedi, MS; Sandeep Lerra, MS(ENT); Piyush Gupta, MS; Prathamesh S. Pai, MS(ENT), DNB; Devendra A. Chaukar, MS, DNB; Jai Prakash Agarwal, MD; Anil K. D'Cruz, MS, DNB


Malignant melanomas involving the mucosa are rare and aggressive lesions. Their rarity has made the formulation of staging and treatment protocols very difficult, as most of the available information comes from case reports and small case series. We conducted a retrospective...

Clinical management of a patient with advanced mucosal malignant melanoma in the sinonasal area

January 21, 2014  |  Marco Fusetti, MD; Alberto Eibenstein, MD; Ettore Lupi, MD; Enzo Iacomino, MD; Tiziana Pieramici, MD; Alessandra Fioretti, MD, PhD


We describe a case of mucosal malignant melanoma in the sinonasal area of a 65-year-old woman. She presented with a history of nasal obstruction and epistaxis with subsequent tenderness, facial anesthesia involving cranial nerve V2, red eye, proptosis, diplopia, and...

Primary amelanotic melanoma of the nasal cavity: A case report

January 21, 2014  |  Seema Gupta, MD; Mohan Chand Pant, MD; Nuzhat Husain, MD; Sham Sundar, MD; Huma Khan, PhD


Primary mucosal malignant melanomas of the nose are rare, accounting for only 0.3 to 2% of all cases of malignant melanoma and about 4% of all head and neck melanomas. The amelanotic variant of mucosal malignant melanoma is even more rare, and the prognosis is poor. This...

Primary mucosal melanoma arising from the eustachian tube with CTLA-4, IL-17A, IL-17C, and IL-17E upregulation

January 24, 2013  |  Calvin Wei, MD; Sasis Sirikanjanapong, MD; Seth Lieberman, MD; Mark Delacure, MD; Frank Martiniuk, PhD; William Levis, MD; Beverly Y. Wang, MD


Primary malignant melanoma arising from the eustachian tube is extremely rare. We report the case of a 63-year-old white man who presented with a 1-month history of left-sided hearing loss and aural fullness. Flexible fiberoptic laryngoscopy detected a blue-purple mass that...

Malignant melanoma metastatic to the larynx: A case report

January 24, 2013  |  Aliasghar Arabi Mianroodi, MD; Tourajreza Mirshekari, MD; Aliakbar Taheri, MD


Malignant melanoma of the larynx is a rare cancer that can appear as a primary tumor or as a metastasis from a cutaneous head and neck primary. To the best of our knowledge, only 60 cases of primary laryngeal melanoma have been reported in the world literature. Melanomas...

Primary mucosal desmoplastic melanoma of the nasal vestibule: The second case

October 27, 2011  |  Sergio S. Cervantes, MD and Reginald Baugh, MD


Primary mucosal desmoplastic melanoma is an exceedingly rare, potentially devastating disease that is often initially misdiagnosed because of its deceptively benign presentation. We report what we believe is only the second case of mucosal desmoplastic melanoma arising from the...

Primary malignant melanoma of the trachea: Case report

July 1, 2010  |  Engin Çekin, MD, Hakan Cincik, MD, Ismail Yilmaz, MD, and Atila Gungor, MD


A 22-year-old man was admitted with complaints of dyspnea and hoarseness. Laryngoscopy and computed tomography of the neck revealed a 1.5 x 2-cm solid mass obstructing the trachea. The black, pedunculated mass was completely removed through a tracheal incision, and a...


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