Fibrosarcoma

Infantile fibrosarcoma of the maxillary sinus: Significant response

March 1, 2012     Enrique Palacios, MD, FACR and Edward C.F. Lam, MD
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Surgical excision with wide margins is the treatment of choice for infantile fibrosarcoma of the maxillary sinus. Chemotherapy can be used for inoperable tumors.

Myofibroma of the zygomatic bone in an older child: A case report

July 13, 2011     Engin Acıoğlu, MD, Gül Özbilen Acar, MD, Yalçın Alimoğlu, MD, Harun Cansız, MD, and Sergülen Dervişoğlu, MD
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Abstract

Myofibroma/myofibromatosis is a rare mesenchymal disorder that is part of a heterogeneous group of approximately 20 disorders that are classified primarily according to the proliferation of benign fibrous elements. These lesions can arise during a wide range of ages, with many occurring in the first decade of life, and they are slightly more common in males than females. The etiology of this disease is not well understood. Clinically, patients with myofibroma/myofibromatosis present with various signs, ranging from superficial, cutaneous, purplish macules to freely movable subcutaneous masses to deep-seated fixed lesions. The definitive diagnosis is made on histopathologic grounds. The destructive clinical behavior of myofibroma/myofibromatosis in the setting of insufficient pre- or perioperative diagnostic evaluations (e.g., a failure to perform fine-needle aspiration or frozen-section biopsy) may guide the clinician toward a radical surgical procedure rather than a simple excision.

A rare sinonasal neoplasm: Fibrosarcoma

April 30, 2011     Sami Bercin, MD, Togay Muderris, MD, Muzaffer Kırıs, Prof. Dr., Alper Kanmaz, MD, and Olcay Kandemir, Prof. Dr.
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Abstract

Sinonasal fibrosarcoma is an infrequently occurring malignant neoplasm. It usually presents with nasal obstruction and epistaxis, as do other sarcomas in this region. The final diagnosis is based on the histopathologic and immunohistochemical examination. We report a case involving a 47-year-old woman with a 2-year history of left nasal obstruction and proptosis, as well as diplopia for the 2 months preceding her visit. Computed tomography and magnetic resonance imaging showed a neoplasm occupying the left nasal cavity, ethmoid sinuses, and bilateral frontal sinuses. The neoplasm also was eroding the medial wall of the maxillary sinus, the lamina papyracea, the cribriform plate, and the anterior wall of the frontal sinus. Complete removal of the tumor was achieved both endoscopically and through a Lynch incision. Sinonasal fibrosarcoma was found on histopathologic examination.

Nasal cavity ossifying fibrosarcoma: An unusual fibro-osseous neoplasm

October 31, 2010     Yadiel A. Alameda, MD, Carlos Perez-Mitchell, MD, and José M. Busquets, MD
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Abstract

We describe the case of a 65-year-old woman who presented with left nasal obstruction. Clinical and radiographic examinations revealed the presence of a soft-tissue mass that had obliterated the left nasal cavity. The mass was completely excised via an endoscopic approach. Histopathologic examination identified the tumor as an ossifying fibrosarcoma. The patient recovered uneventfully and remained free of disease at the 2-year postoperative follow-up. To the best of our knowledge, no case of an ossifying fibrosarcoma of the nasal cavity has been previously reported in the English-language literature. We discuss the features of this case and the clinical presentation, diagnosis, and management of fibrosarcomas of the nasal cavity and paranasal sinuses.

Congenital/infantile fibrosarcoma in a 3-week-old boy

March 31, 2008     Dary J. Costa, MD, Ron B. Mitchell, MD, and David S. Brink, MD
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