Recurrent infantile myofibromatosis: A report of conservative management and discussion of treatment strategies

December 1, 2008     Charles S. Ebert Jr., MD, MPH, Carlton Zdanski, MD, Farhad Ardeshirpour, MD, Mihir Patel, MD, Craig F. Hart, MD, and Amelia F. Drake, MD


Infantile myofibromatosis is a rare proliferative mesenchymal disorder that has a potential for rapid growth and recurrence. Approximately 30% of infantile myofibromatosis lesions present in the head and neck, and some of these can cause significant morbidity. We report a case of recurrent infantile myofibromatosis that persisted after surgery and chemotherapy and was managed conservatively. Treatment of infantile myofibromatosis varies according to the size, location, and extent of disease. Solitary lesions may be simply observed in view of their potential for regression, but surgical excision, radiotherapy, and/or chemotherapy should be considered on a case-by-case basis, especially for nonresectable, rapidly progressive, or symptomatic lesions.

Juvenile nasopharyngeal angiofibroma: Spontaneous resolution

August 31, 2008     Patrick M. Spielmann, MRCSEd, Richard Adamson, FRCS, Kenneth Cheng, MRCS, and Robert J. Sanderson, FRCS†


Juvenile nasopharyngeal angiofibroma is a rare, benign tumor that occurs most often in adolescent males. Common practice is to excise the tumor with open or endoscopic surgery. We report the case of a 17-year-old male who presented in 1995 with a mass filling the left posterior nasal cavity. A diagnosis of juvenile nasopharyngeal angiofibroma was obtained with computed tomography and magnetic resonance imaging. The patient elected to have no treatment. On annual scans, the lesion changed little until 1998, when it began to gradually decrease in size. Although it is not well proven, the natural history of these tumors seems to be regression over time. This case supports the argument that a policy of watchful waiting with regular imaging studies may postpone or eliminate the need for surgery and its attendant risks.

Nasopharyngeal angiofibroma

April 30, 2008     Ryan Kau, BS, Mala Tanna, BA, Sasmita Misra, MD, and Alejandro Luina Contreras, MD

An aggressive psammomatoid ossifying fibroma of the sinonasal tract: Report of a case

June 30, 2007     Bijan Khademi, MD; Nika Niknejad, MD; Jalal Mahmoudi, MD
Aggressive psammomatoid ossifying fibromas (APOFs) represent a subgroup of related fibro-osseous lesions that appears to be unique to the nasal cavity, paranasal sinuses, and orbit. These rare lesions are characterized by distinctive histomorphologic features and a tendency to affect younger patients. Histologically they are benign, but clinically they are locally aggressive. We report the case of a 15-year-old boy who had a large APOF in the left ethmoid and sphenoid sinuses. The location of this tumor made this case unusual.

Isolated cementoossifying fibroma of the ethmoid bulla: A case report

April 30, 2006     Ismail Yilmaz, MD; Nebil Bal, MD; Levent N. Ozluoglu, MD
Cementoossifying fibroma is a rare nonodontogenic tumor of the periodontal membrane that arises from the mesodermal germ layer. This nonneoplastic, locally destructive tumor has occurred as an osseous lesion in the mandible, the maxilla, the zygoma, all the paranasal sinuses, and the orbital and petromastoid regions. It has occurred as an extraosseous lesion in the gingiva and the auricle. The diagnosis requires correlating a variety of clinical, radiologic, and histologic factors. The recurrence rate is high, particularly for lesions in the paranasal sinuses. Surgical management via a local excision as wide as possible is suggested. We describe the case of a 32-year-old woman with an isolated cementoossifying fibroma of the right ethmoid bulla, and we review the diagnosis, differential diagnosis, and management of this tumor.

Ossifying fibroma of the ethmoid sinus

February 1, 2006     Enrique Palacios, MD, FACR

Ossifying fibroma of the maxilla

July 31, 2004     Hugh Robertson, MD, FACR; Enrique Palacios, MD, FACR

Ossifying fibroma of the jaw

June 30, 2004     Francis H. Gannon, MD; Lester D.R. Thompson, MD

Myofibroma of the cheek: A case report

May 31, 2004     Tali L. Kassenoff, BA; Abtin Tabaee, MD; Ashutosh Kacker, MD
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