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Case report: Paraneoplastic neurologic syndrome associated with squamous cell carcinoma of the tonsil

October 24, 2013  |  Jeffrey R. Janus, MD; Sivakumar Chinnadurai, MD; Eric J. Moore, MD


Paraneoplastic syndromes include a variety of disorders that affect the neurologic, endocrine, mucocutaneous, hematologic, and other systems as a result of neoplastic disease. Although their presentations vary, syndromes occur when tumor antigens exhibit cross-reactivity to...

Synchronous verrucous carcinoma and inverted papilloma of the lacrimal sac: Case report and clinical update

October 24, 2013  |  Cheryl Gustafson, MD; Eugene Einhorn, MD; Mary H. Scanlon, MD; Kenneth E. Morgenstern, MD; Paul J. Howlett, MD; Noam A. Cohen, MD, PhD


Inverted papilloma is a benign epithelial tumor of the nasal cavity. It is known to coexist with malignancy in 5 to 13% of cases, with squamous cell carcinoma being the most common malignancy. Another associated malignancy, one that is extremely rare, is verrucous carcinoma. To...

Undifferentiated thyroid carcinoma

October 24, 2013  |  Lester D.R. Thompson, MD

Histologically, undifferentiated thyroid carcinomas show a variety of patterns, from sheet-like, storiform, fascicular, angiomatoid, and meningothelial to solid, exhibiting extensive lymph-vascular invasion.

Thyroglossal duct cyst carcinoma: Case report and review of the literature

September 19, 2013  |  David W. Jang, MD; Andrew G. Sikora, MD, PhD; Anatoly Leytin, MD


Well-differentiated thyroid carcinoma of a thyroglossal duct cyst (TGDC) is a rare entity, found in about 1% of all TGDCs. Diagnosis is usually made incidentally after a Sistrunk procedure. Options for further therapy include total thyroidectomy, T4 suppression therapy, and...

Acantholytic squamous cell carcinoma of the maxilla: Unusual location and aggressive behavior of a rare histologic variant

September 19, 2013  |  Ozan Bagis Ozgursoy, MD; Ozden Tulunay, MD; Sami Engin Muz, MD; Gaffar Aslan, MD; Babur Kucuk, MD


Acantholytic squamous cell carcinoma (ASCC) of the mucosal membranes has been documented sporadically. The highly aggressive behavior of a mucosal ASCC arising in the oral cavity has been recently reported. To the best of our knowledge, only 1 autopsy case of maxillary ASCC...

Practical applications of in-office fiberoptic transnasal esophagoscopy in the initial evaluation of patients with squamous cell cancer of the head and neck

September 19, 2013  |  Robert W. Dolan, MD; Timothy D. Anderson, MD


We conducted a study to analyze the effectiveness of transnasal esophagoscopy (TNE) as an alternative to operative endoscopy (OE) for the evaluation of primary head and neck cancers and for the surveillance of synchronous esophageal cancers. Our study population was made up of...

Lymphoepithelial carcinoma of the parotid gland, a very unusual tumor: Case report and review

September 19, 2013  |  Natarajan Anantharajan, MRCS, MCh; Nagamuttu Ravindranathan, FRCS, FDRCS; Pathmanathan Rajadurai, MBBS, FRCPA


Lymphoepithelial carcinoma (LEC) of the parotid gland is rare. When it does occur, it is usually seen in Asians and Greenland Eskimos. An association with Epstein-Barr virus (EBV) infection has been documented. We report a case of EBV-associated LEC of the parotid gland in a 30...

Endometrial carcinoma metastatic to the retromolar pad

September 19, 2013  |  Hisham Hatoum, DDS; Bruno C. Jham, DDS, MS, PhD; Karen Garber, DMD; Jaime S. Brahim, DDS, MS; Mark A. Scheper, DDS, PhD


Metastatic carcinoma from the female genitalia to the oral mucosa is exceptionally rare, with only 11 such cases having been previously reported in the English-language literature. We describe a new case in a 65-year-old woman with a history of endometrial carcinoma who...

Mucoepidermoid carcinoma presenting as a large cyst of the parotid gland in HIV disease

July 22, 2013  |  Nelson Goldman, MD; Sania Shuja, MD; Raafat Makary, MD; Reginald L. Griffin, MD


Cystic lesions of the parotid gland may be the presenting symptom in human immunodeficiency virus (HIV)-positive patients. The most common lesion is the benign lymphoepithelial cyst. Malignant lesions may also be associated with-or be hidden by-a cystic mass. We report a case...

Wrong egg in the usual nest: Thyroid papillary carcinoma within a branchial cleft cyst

July 22, 2013  |  Mustafa Sagit, MD; Ayhan Gokler, MD; Istemihan Akin, MD; Unsal Han, MD


Branchial cleft cysts are the most common lesions to arise laterally in the neck. Ectopic thyroid tissue within a branchial cleft cyst is rare, and a papillary carcinoma arising from this tissue is extremely rare. We present a case of a lateral neck cyst representing a primary...

Metastatic choriocarcinoma: A rare presentation as a neck mass

June 12, 2013  |  Hilmi Alper Senkal, MD; Taner Yilmaz, MD; and Ahmet Bulent Sozeri, MD


Testicular carcinoma metastatic to the neck is rare. Even more rare is a finding of choriocarcinoma as a neck mass without any sign of a primary testicular tumor, as only a few cases have been reported in the literature. We describe a new case that occurred in a 29-year-old man...

Oropharyngeal squamous cell carcinoma metastatic to lower-extremity soft tissues: A case report and literature review

June 12, 2013  |  Jason M. Samuelian, DO; Brandon J. Fisher, DO; Larry C. Daugherty, MD; and Usha A. Babaria, MD


A 52-year old man was referred to our service for evaluation after being diagnosed with oropharyngeal squamous cell carcinoma. Contrast-enhanced computed tomography (CT) revealed a mass in the left tonsillar pillar, as well as submental lymphadenopathy. The extent of tumor...


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