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Carcinoma

Secretory carcinoma

December 7, 2016  |  Lester D. Thompson, MD

This tumor presents as a solitary, circumscribed but not encapsulated mass, although it may have invasive borders.

Risk of thyroid malignancy following an index head and neck squamous cell carcinoma: A population-based study

December 7, 2016  |  Jason Y. Chan, MBBS; Zhen Gooi, MBBS; Wojciech K. Mydlarz, MD; Nishant Agrawal, MD

Abstract

To evaluate the incidence of a subsequent primary thyroid malignancy in patients with an index head and neck squamous cell carcinoma (HNSCC), we analyzed the National Cancer Institute's Surveillance, Epidemiology, and End Results database to identify a cohort of patients who...

End-of-life decision making in geriatric terminal head and neck cancer

December 7, 2016  |  Kourosh Parham, MD, PhD, FACS; Karen M. Kost, MD, FRCSC

In the oncogeriatric setting, the comprehensive geriatric assessment has been recognized as providing useful information supplementary to what can be obtained via standard oncology status assessments.

Prognostic factors in metastatic cutaneous squamous cell carcinoma of the head and neck

October 25, 2016  |  Gideon Bachar, MD; Aviram Mizrachi, MD; Naomi Rabinovics, MD; Dan Guttman, MD; Thomas Shpitzer, MD; Dean Ad-El, MD; Tuvia Hadar, MD

Abstract

Metastatic cutaneous squamous cell carcinoma (SCC) of the head and neck poses a significant therapeutic challenge due to its aggressive biologic behavior. We conducted a retrospective study of 71 patients-58 men and 13 women, aged 28 to 88 years (mean: 71)-who had been treated...

Cervical metastasis in squamous cell carcinoma of the hard palate and maxillary alveolus

October 25, 2016  |  Yekaterina Koshkareva, MD; Jeffrey C. Liu, MD; Miriam Lango, MD; Thomas Galloway, MD; John P. Gaughan, PhD; John A. Ridge, MD, PhD

Abstract

We conducted a retrospective study to determine the incidence and treatment outcomes of neck metastases in patients with squamous cell carcinoma (SCC) of the hard palate and/or maxillary alveolus after surgical excision of the primary tumor. We also sought to identify any risk...

Primary salivary duct carcinoma arising from the Stensen duct

September 19, 2016  |  Kenji Noda, MD; Takashi Hirano, MD, PhD; Tomoyo Okamoto, MD; Masashi Suzuki, MD, PhD

Abstract

This report describes a salivary duct carcinoma (SDC) arising from the extraglandular portion of the Stensen duct. The patient was a 56-year-old man who presented with a palpable, elastic, hard mass without tenderness in the right cheek. Computed tomography revealed a tumor of...

Parotid gland metastasis in Merkel cell carcinoma of the head and neck: A series of 14 cases

September 19, 2016  |  Kristine E. Day, MD; William R. Carroll, MD; Eben L. Rosenthal, MD

Abstract

Merkel cell carcinoma (MCC) is a rare cutaneous cancer of neuroendocrine cell origin that occurs frequently on the head and neck. With a high incidence of local recurrence and regional and distant metastasis, it carries a poor prognosis. We performed a retrospective study to...

Postoperative hypofunctioning of the thyroid gland after total laryngectomy

August 21, 2016  |  Sirshak Dutta, MS, DLO; Kaustuv Das Biswas, MS, DLO; Soumya Ghatak, MS; Dibakar Haldar, MD; Indranil Sen, MS; Ramanuj Sinha, MS, DNB

Abstract

Primary laryngeal carcinoma is a common cancer, predominantly affecting males. Hypothyroidism is an undesirable sequela of both surgery and radiotherapy, the two most commonly used modalities of treatment. For advanced cases, standard treatment protocol includes total...

p53 codon 72 polymorphism and its overexpression in patients with laryngeal carcinoma: Prognostic implications

June 14, 2016  |  Gopika Kalsotra, MD; Ashok K. Gupta, MD; Rijuneeta Gupta, MD; Ritu Rathi, PhD; Rajender Prasad, PhD

Abstract

Abnormalities in the p53 gene are the most common genetic alterations seen in laryngeal carcinoma. No data exist regarding the association between laryngeal carcinoma and a distinct codon 72 variant and its expression. We conducted a prospective study (1) to analyze the p53...

Coexistent chronic myelogenous leukemia with squamous cell carcinoma of the larynx associated with NOD2/CARD15 mutation in a young adult

June 14, 2016  |  Marcin Fraczek, MD; Agnieszka Stembalska, MD; Pawel Karpinski, MD; Tomasz Krecicki, MD

Abstract

We report the case of a 37-year-old man with human papillomavirus-positive squamous cell carcinoma of the larynx coexisting with chronic myelogenous leukemia. The patient had no history of smoking or alcohol consumption. Within a few months, his rapidly growing tumor was...

Synchronous bilateral tonsillar squamous cell carcinoma related to human papillomavirus: Two case reports and a brief review of the literature

April 30, 2016  |  Allison Rasband-Lindquist, MD; Yelizaveta Shnayder, MD; Maura O'Neil, MD

Abstract

Human papillomavirus (HPV) was recently identified as a risk factor for oropharyngeal squamous cell carcinoma (SCC) independent of tobacco and alcohol use. The prognosis of patients with HPV-related oropharyngeal carcinomas is better than that for patients with non-HPV-related...

Is unenhanced 18F-FDG-PET/CT better than enhanced CT in the detection of retropharyngeal lymph node metastasis in nasopharyngeal carcinoma?

April 30, 2016  |  Iuan-Sheng Wu, MD; Guang-Uei Hung, MD; Bo-Ling Chang, MD; Chi-Kuang Liu, MD; Tung-Hao Chang, MD; Hong-Shen Lee, PhD; Mu-Kuan Chen, MD, MS, PhD

Abstract

Positron-emission tomography/computed tomography (PET/CT) has been proposed as a means to enhance the pretreatment evaluation of cervical lymph node status in patients with nasopharyngeal carcinoma (NPC). We conducted a prospective study to compare PET/CT and enhanced CT for...

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