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Carcinoma

Primary salivary duct carcinoma arising from the Stensen duct

September 19, 2016  |  Kenji Noda, MD; Takashi Hirano, MD, PhD; Tomoyo Okamoto, MD; Masashi Suzuki, MD, PhD

Abstract

This report describes a salivary duct carcinoma (SDC) arising from the extraglandular portion of the Stensen duct. The patient was a 56-year-old man who presented with a palpable, elastic, hard mass without tenderness in the right cheek. Computed tomography revealed a tumor of...

Parotid gland metastasis in Merkel cell carcinoma of the head and neck: A series of 14 cases

September 19, 2016  |  Kristine E. Day, MD; William R. Carroll, MD; Eben L. Rosenthal, MD

Abstract

Merkel cell carcinoma (MCC) is a rare cutaneous cancer of neuroendocrine cell origin that occurs frequently on the head and neck. With a high incidence of local recurrence and regional and distant metastasis, it carries a poor prognosis. We performed a retrospective study to...

Postoperative hypofunctioning of the thyroid gland after total laryngectomy

August 21, 2016  |  Sirshak Dutta, MS, DLO; Kaustuv Das Biswas, MS, DLO; Soumya Ghatak, MS; Dibakar Haldar, MD; Indranil Sen, MS; Ramanuj Sinha, MS, DNB

Abstract

Primary laryngeal carcinoma is a common cancer, predominantly affecting males. Hypothyroidism is an undesirable sequela of both surgery and radiotherapy, the two most commonly used modalities of treatment. For advanced cases, standard treatment protocol includes total...

Coexistent chronic myelogenous leukemia with squamous cell carcinoma of the larynx associated with NOD2/CARD15 mutation in a young adult

June 14, 2016  |  Marcin Fraczek, MD; Agnieszka Stembalska, MD; Pawel Karpinski, MD; Tomasz Krecicki, MD

Abstract

We report the case of a 37-year-old man with human papillomavirus-positive squamous cell carcinoma of the larynx coexisting with chronic myelogenous leukemia. The patient had no history of smoking or alcohol consumption. Within a few months, his rapidly growing tumor was...

p53 codon 72 polymorphism and its overexpression in patients with laryngeal carcinoma: Prognostic implications

June 14, 2016  |  Gopika Kalsotra, MD; Ashok K. Gupta, MD; Rijuneeta Gupta, MD; Ritu Rathi, PhD; Rajender Prasad, PhD

Abstract

Abnormalities in the p53 gene are the most common genetic alterations seen in laryngeal carcinoma. No data exist regarding the association between laryngeal carcinoma and a distinct codon 72 variant and its expression. We conducted a prospective study (1) to analyze the p53...

Is unenhanced 18F-FDG-PET/CT better than enhanced CT in the detection of retropharyngeal lymph node metastasis in nasopharyngeal carcinoma?

April 30, 2016  |  Iuan-Sheng Wu, MD; Guang-Uei Hung, MD; Bo-Ling Chang, MD; Chi-Kuang Liu, MD; Tung-Hao Chang, MD; Hong-Shen Lee, PhD; Mu-Kuan Chen, MD, MS, PhD

Abstract

Positron-emission tomography/computed tomography (PET/CT) has been proposed as a means to enhance the pretreatment evaluation of cervical lymph node status in patients with nasopharyngeal carcinoma (NPC). We conducted a prospective study to compare PET/CT and enhanced CT for...

Synchronous bilateral tonsillar squamous cell carcinoma related to human papillomavirus: Two case reports and a brief review of the literature

April 30, 2016  |  Allison Rasband-Lindquist, MD; Yelizaveta Shnayder, MD; Maura O'Neil, MD

Abstract

Human papillomavirus (HPV) was recently identified as a risk factor for oropharyngeal squamous cell carcinoma (SCC) independent of tobacco and alcohol use. The prognosis of patients with HPV-related oropharyngeal carcinomas is better than that for patients with non-HPV-related...

A case of minocycline-induced black thyroid associated with papillary carcinoma

March 16, 2016  |  Kohei Nishimoto, MD, PhD; Yoshihiko Kumai, MD, PhD; Daizo Murakami, MD, PhD; Eiji Yumoto, MD, PhD

Abstract

We report a rare case of black thyroid accompanied by papillary carcinoma in a patient with an extended history of minocycline treatment. A 78-year-old man was referred to our outpatient clinic with swelling in his neck. He had been taking minocycline for the previous 2 years...

Papillary carcinoma in thyroglossal duct cyst: Two case reports and review of the literature

March 16, 2016  |  Neil S. Patel, MD; Kianoush Sheykholeslami, MD, PhD

Abstract

The thyroglossal duct cyst is one of the more common congenital anterior neck masses. In rare cases, carcinoma has been detected within one of these cysts on histopathologic analysis of resected tissue. Since the incidence of thyroglossal duct cyst carcinoma is low, the...

Metastatic pilomatrix carcinoma: Not so rare after all? A case report and review of the literature

March 16, 2016  |  Daniel M. Walker, MBBS; Samuel Dowthwaite, MBBS, FRACS; Drew Cronin, MBBS; Tristan Molden-Hauer, MBBS; Brent McMonagle, MBBS, FRACS

Abstract

Pilomatrixoma is a slowly growing benign tumor of the dermal hair cells. Metastatic disease is exceptionally rare. Pilomatrixoma can occur at any age, but most patients are older than 40 years at presentation. Approximately 60% of these lesions occur in the head and neck region...

Risk factors for cervical lymph node metastasis in papillary thyroid microcarcinoma: A meta-analysis

February 24, 2016  |  Nopawan Vorasubin, MD; Chau Nguyen, MD, FACS; Marilene Wang, MD

Abstract

A number of studies of predictive factors for lymph node metastasis in papillary thyroid microcarcinoma have been published. We conducted a systematic meta-analysis of some of these studies, and we present our findings herein. We searched the PubMed database and found 13...

Concurrent chemoradiotherapy with capecitabine/cisplatin versus 5-fluorouracil/cisplatin in resectable laryngohypopharyngeal squamous cell carcinoma

February 24, 2016  |  Dongbin Ahn, MD; Jin Ho Sohn, MD, PhD; Jae Hyug Kim, MD; Jeong Eun Lee, MD; Shin Hyung Park, MD; Jae Chul Kim, MD

Abstract

A combination of 5-fluorouracil and cisplatin (FP regimen) is widely used as a standard treatment for head and neck cancer. Recently, capecitabine has received increased attention. We conducted a retrospective study to compare the efficacy and safety of the FP regimen with that...

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