Sinonasal intestinal-type adenocarcinoma

August 31, 2006     Enrique Palacios, MD, FACR; Rafael Rojas, MD

Polymorphous low-grade adenocarcinoma at the base of the tongue: An unusual location

December 1, 2005     Alfio J. Tincani, MD, PhD; Albina Altemani, MD, PhD; Antonio S. Martins, MD, PhD; Gilson Barreto, MD; João B. Valério, MD; André Del Negro, MD; Priscila P.C. Araújo, MD
Polymorphous low-grade adenocarcinoma (PLGA) is a malignant neoplasm of low aggressiveness that occurs almost exclusively in the minor salivary glands, primarily those in the palate. We report a case of PLGA that arose in the base of the tongue and subsequently metastasized to the neck. The tumor was resected through the oral cavity with wide margins and dissection. The neck metastasis was treated with radical neck dissection and radiotherapy. The patient recovered and remained disease-free at follow-up 30 months later. This case shows that PLGA, which has a variable morphologic appearance, can occur at sites other than the salivary glands.

Recurrent polymorphous low-grade adenocarcinoma manifesting as a sinonasal mass: A case report

May 31, 2005     Daniel D. Charous, MD; Mary F. Cunnane, MD; Marc R. Rosen, MD; William M. Keane, MD
Polymorphous low-grade adenocarcinoma (PLGA) is a malignant neoplasm that tends to follow a benign clinical course. Recurrences are uncommon. We report a case of recurrent PLGA of the paranasal sinuses that manifested as a large mass that filled the entire nasal cavity and left maxillary sinus. To our knowledge, this is the first reported case of a recurrent PLGA of the paranasal sinuses.

Metastasis of colonic adenocarcinoma to the external ear canal: An unusual case with a complex pattern of disease progression

January 1, 2005     Henry J. Carson, MD; Jeffrey S. Krivit, MD; Stanley G. Eilers, MD
We report on a patient who developed far-ranging metas-tases of adenocarcinoma of the colon that followed a gradual cephalad progression, including the right external ear canal, and led to hearing loss. The patient was a 63-year-old white male with stage III adenocarcinoma of the colon. After 2 years with metastases elsewhere, he developed hearing loss on the right side. Physical examination of the head and neck showed a mass in the external ear canal, and biopsy confirmed adenocarcinoma. After removal, the patient's hearing improved. This case is interesting not only because of the unusual metastasis to the external ear canal, but also because of the patient's previous history of metastasis over the course of more than 2 years. The significance of such wide-ranging metastases is that metastasis of adenocarcinoma to the ear did not signal imminent death, and relief of the hearing loss it caused was possible.
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