Thyroid

Thyroidectomy for substernal goiter via a mediastinoscopic approach

July 31, 2006     Veling W. Tsai, MD, JD; Robert B. Cameron, MD; Marilene B. Wang, MD
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Abstract
We report an unusual case in which a patient presented with a large posterior mediastinal goiter that extended to the level of the aorta. The goiter was resected through a standard Kocher neck incision with mediastinoscopic assistance. The large goiter was completely excised without the need for a sternotomy.

Warthin-like tumor of the thyroid gland: An uncommon variant of papillary thyroid cancer

January 1, 2006     Harold H. Kim, MD; David Myssiorek, MD; Keith S. Heller, MD; Fazlur Zahurullah, MD; Tawfiqul Bhuiya, MD
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Abstract
Several variants of papillary thyroid cancer have been described, including, most recently, Warthin-like tumor of the thyroid gland. To bring attention to this uncommon variant, we review previous reports on this entity and we add 5 new cases to the literature. We retrospectively reviewed the records of all patients who had undergone thyroidectomy at our institution during a 7-year period. Among these cases, we identified 5 patients who had had a Warthin-like tumor of the thyroid. From their charts, we compiled data on age, sex, lymphadenopathy, distant spread, and treatment. Pathologic specimens were reviewed for tumor size, capsular invasion, and vascular invasion. All 5 patients were women (mean age: 51.6 yr). Tumor size ranged from 0.9 to 2.0 cm. Multifocality was seen in 1 of the 5 patients; this patient was also the only one who experienced capsular and vascular invasion. No patient had lymph node spread or distant metastasis. Because the follow-up period among these patients was still short, we were unable to analyze long-term survival data.

Electrophysiologic laryngeal nerve monitoring in high-risk thyroid surgery

May 31, 2005     Phillip Song, MD; Larry Shemen, MD, FRCS, FACS
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Abstract
We recently began performing intraoperative electrophysiologic monitoring of the recurrent laryngeal nerve and the external branch of the superior laryngeal nerve during high-risk thyroidectomies. Neuromonitoring can detect stimulation of these nerves and thereby prevent a mechanical or thermal injury that can result in neurapraxia or axonotmesis. Monitoring is also useful during dissection in an already operated-on field, when performing thyroidectomy on patients who depend on their voice for their livelihood, and when removing a large goiter or mediastinal mass.

Diagnostic accuracy of palpation-guided and image-guided fine-needle aspiration biopsy of the thyroid

May 31, 2005     Steven L. Goudy, MD; Michael B. Flynn, MD
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Abstract
We conducted a retrospective study to compare the sensitivity and specificity of traditional palpation-guided fine-needle aspiration biopsy (FNAB) performed by clinicians and pathologists with that of image-guided FNAB performed by radiologists for the evaluation of thyroid nodules. We reviewed the medical records of 89 patients who had undergone thyroid FNAB and subsequent surgical excision and pathology. Of this group, 58 patients had undergone palpation-guided FNAB performed by a clinician, 20 had undergone palpation-guided FNAB performed by a pathologist, and 11 had undergone image-guided FNAB performed by a radiologist. The sensitivity of the three techniques was 86, 100, and 100%, respectively, and the specificity was 78, 94, and 44%; there were no statistically significant differences in sensitivity or specificity among the three groups. Our data indicate that FNAB of the thyroid can be performed with equal reliability by clinicians, pathologists, and radiologists.

Dyshormonogenetic goiter of the thyroid gland

April 1, 2005     Lester D.R. Thompson, MD
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Papillary thyroid carcinoma

September 30, 2004     Brenda L. Nelson, DDS; Lester D.R. Thompson, MD
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Various presentations of fourth branchial pouch anomalies

August 31, 2004     Anita Jeyakumar, MD; Arthur S. Hengerer, MD
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Abstract
Embryologic anomalies of the fourth branchial pouch are rarely seen. They usually present as recurring episodes of deep neck infections and/or abscesses or acute suppurative thyroiditis. Failure to recognize these unusual cases may result in misdiagnosis, inadequate treatment, and subsequent recurrence. We report 3 cases of patients with fourth branchial anomalies. Diagnosis starts with a preoperative evaluation consisting of a barium swallow or sonogram followed by direct hypopharyngoscopy at the time of surgery. Treatment of acutely infected sinuses is best done with appropriate antibiotics and, if necessary, with incision and drainage. Surgical excision should be planned after the inflammation has completely resolved.
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