October 31, 2010 Lester D.R. Thompson, MD
May 31, 2010 Ryan F. Osborne, MD, Lorraine M. Smith, MD, and Reena Gupta, MD
May 31, 2010 Rafa El Gehani, BDS, MDentSc, FFDRCSI, MOSRCSEd, Balasubramanian Krishnan, MDS, DNB, MOMS RCPS(Glasg), and Mohammed I.L. Shehoumi, BDS
article
Abstract
Sialolithiasis is one of the most common diseases of the salivary gland, but giant sialoliths have been reported in the literature infrequently. The submandibular gland and its duct appear to be the sites most susceptible to this disease. We report 2 cases of giant sialoliths occurring solely in the submandibular duct. In both cases, transoral removal of the stone was performed under local anesthesia; one of the stones was 35 mm long and the other was 25 mm long. The patients' glands were managed conservatively with sialagogues and analgesics. The glands recovered normal function quickly after removal of the stones, which is noteworthy because such long-standing stones usually produce irreversible functional damage. Follow-up showed asymptomatic and normally functioning glands. The authors conclude that a conservative approach will spare the patient the morbidity associated with gland removal.
February 1, 2010 Moses A. Yaor, MBBS, DLO, FRCSEd (Otol)
article
Abstract
Salivary glands are the site of a wide variety of histopathologic types of benign and malignant tumors. The author reviewed 23 articles from 12 African countries published between 1980 and 2004 to examine patterns of salivary gland tumors. These neoplasms represent a significant health problem in Africa. The author found that patterns of presentation are different from those seen in Western countries; for example, African patients are generally younger at presentation. Also, there may be a female preponderance in Africa, and Warthin tumor is rare.
June 30, 2009 Banu Dogan Gun, MD, Sukru Oguz Ozdamar, MD, Burak Bahadir, MD, and Lokman Uzun, MD
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Abstract
Salivary gland tumors that display myoepithelial differentiation exclusively or predominantly are relatively uncommon, and the assessment of malignancy in a myoepithelial tumor can be difficult. We report a case of parotid gland myoepithelioma composed predominantly of spindle cells with focal capsular invasion. The patient was a 65-year-old woman who presented with a painless mass in the right preauricular region. Histologically, the tumor had a solid and multinodular growth pattern and was predominantly made up of spindle cells with a minor component of epithelioid cells with moderate cellular atypia. Focal regions of tumor cells infiltrated the capsule with tongue-like processes, but tumor infiltration into the adjacent parotid tissue was absent. The tumor cells showed strong cytoplasmic immunoexpression of vimentin, pankeratin, S-100 protein, and smooth-muscle actin. Immunostains with glial fibrillary acidic protein, melanoma marker, epithelial membrane antigen, and carcinoembryonic antigen were negative. Expression of p53 was observed focally in the nuclei of the tumor cells. A final diagnosis of salivary gland myoepithelioma with focal capsular invasion was made, and the case was regarded as a myoepithelial tumor of uncertain malignant potential. In this report, we discuss the histologic criteria required to diagnose malignancy in salivary gland myoepithelial tumors.
March 1, 2009 Neel Gupta, MD, Enrique Palacios, MD, FACR, and Shannon Barry, MS
February 1, 2009 Robert L. Witt, MD, FACS and Patrick A. Wilson, MD, FCAP
article
Abstract
Small-cell carcinoma of a minor salivary gland is a rare and to the best of our knowledge previously unreported cause of vocal fold immobility. We describe the case of a 68-year-old woman who presented with hoarseness, dysphagia, and weight loss. Examination revealed left vocal fold immobility. She had no other obvious abnormality of the upper airway, neck, or skin. Computed tomography and magnetic resonance imaging demonstrated a 4-cm submucosal oropharyngeal mass with extension to the parapharyngeal space and involvement of the carotid sheath and the foramen ovale at the skull base; imaging also revealed cervical adenopathy. Fine-needle aspiration biopsy identified the mass as a small-cell carcinoma, a finding that was confirmed by immunohistochemistry. Extensive tumor invasion and multiple comorbidities precluded an aggressive management strategy, and the patient was treated palliatively. She died of her disease shortly after her diagnosis. Vocal fold immobility of unknown etiology mandates imaging from the skull base to the upper mediastinum.
September 25, 2008 Sanjay Verma, MBBCh, MA, FRCS (ORL-HNS), PhD, Perumal Chokkalingam, BSc, FRCS, and Duncan McRae, FRCS, FRCS (ORL-HNS)
article
Abstract
We report an unusual case of a young woman with chondrosarcoma affecting the greater cornu of the hyoid bone. Only a handful of reports of primary chondrosarcoma involving the hyoid exist in the world literature. The case described presented as a swelling in the submandibular triangle, and as such posed a particular clinical and radiologic diagnostic challenge. Our subsequent surgical management of this rare entity comprised local excision followed by close observation, and is defined in the context of the existing literature. Two years after surgery, the patient remained free of tumor recurrence; she was subsequently lost to follow-up.
September 30, 2007
article
Maryam Kadivar, MD, APCP;
Yalda Nilipour, MD;
Alireza Sadeghipour, MD, APCP
Abstract
Primary giant-cell tumor of the salivary gland is a rare lesion with an incompletely characterized histogenesis. To the best of our knowledge, only 16 cases have been previously documented in the English-language literature. We report a new case, which occurred in a 75-year-old man who presented with a parotid mass and cervical lymphadenopathy. The patient underwent a left total parotidectomy and cervical lymph node dissection. As far as we know, ours is the only reported case of a primary giant-cell tumor of the salivary gland in which the patient presented with lymph node metastasis. Because so little is known about giant-cell tumor of the salivary gland, we use the occasion of this case report to describe the cytologic, histologic, and immunohistochemical characteristics that we observed.
April 30, 2007 Heike Varnholt, MD; Lester D.R. Thompson, MD, FASCP; Liron Pantanowitz, MD
August 31, 2006 Pavel Komínek, MD, PhD; Petr Blasch, MD
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Abstract
Necrotizing sialometaplasia is a benign, spontaneously healing inflammatory condition. It usually affects the hard palate, and it can mimic a malignancy both clinically and histologically. We report a new case of this rare disorder.
June 30, 2006 D.J. Verret, MD; Rene L. Galindo, MD, PhD; Robert J. DeFatta, MD, PhD; Paul W. Bauer, MD
article
Abstract
A sialoblastoma is a rare congenital epithelial tumor that arises in a major salivary gland. To our knowledge, only 24 cases of sialoblastoma have been previously reported in the English-language literature. We report a new case, that of a 15-month-old boy who presented with a submandibular mass. Surgical excision of the mass was undertaken. Intraoperatively, the mass appeared to be adjacent to the submandibular gland, but it had not invaded it. The mass was excised, and the submandibular gland was left in place. Pathology identified the tumor as a sialoblastoma. However, pathology also revealed that residual tumor was present at the surgical margin. The patient was returned to the operating room for excision of the left submandibular gland and the level I lymph nodes. Following revision surgery, the surgical margins were negative. The patient remained disease-free at the 1-year follow-up. Despite the need for revision surgery, this case provides support for the idea that surgery alone is sufficient for curative treatment.
