Wegener granulomatosis

January 24, 2013
| Reprints
Pathology Clinic

Wegener granulomatosis presents clinically as ulcerative and crusted lesions with tissue destruction.

Wegener granulomatosis (WG) is an idiopathic, nonneoplastic, aseptic, necrotizing disease characterized by vasculitis and destructive properties. In general, affected patients exhibit disease in the sinonasal tract, lungs, and kidney, in some cases metachronously. Patients may present with systemic or localized disease; patients with systemic disease are usually quite sick. Disease progression may be seen when localized disease becomes systemic, but many patients will remain with limited disease.

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