Liposarcomas of the head and neck are rare, owing to the paucity of adipose tissue in this region. We present what we believe is a unique case of a myxoid liposarcoma in the infraorbital region, which arose in a 38-year-old man. The patient had presented with a slowly growing mass under his left eye that had been present for about 3 months. A wide local excision was performed, and the tumor was removed in its entirety. The final pathology report identified the mass as a well-differentiated myxoid liposarcoma. The patient's postoperative course was uneventful, and at the 12-month follow-up, he exhibited no evidence of disease.