Radiation-induced osteosarcoma of the larynx: Case report and literature review

October 8, 2012
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Laryngeal osteosarcoma is an extremely rare disease. Only 23 cases have been published in the literature. Radiation-induced laryngeal osteosarcoma is even rarer; this is only the third such case to be reported. A 59-year-old man underwent radiotherapy for an in situ laryngeal squamous cell carcinoma at another institution. Five years later he developed a laryngeal osteosarcoma, and a total laryngectomy was performed. Although previous reports showed a poor prognosis, our patient was without disease at the 8-year follow-up. To the best of our knowledge, this is the longest disease-free follow-up to be reported in the literature. We also present a review of the world’s literature.


Sarcomas are rarely seen in the larynx, representing less than 1% of laryngeal neoplasms.1,2The most common form is the chondrosarcoma, which is followed by the fibrosarcoma; osteosarcoma is the rarest type. Currently, there are 23 cases of laryngeal osteosarcoma reported in the literature. This is the third reported case of radiation-induced laryngeal osteosarcoma of the head and neck.1,2In this article we describe this rare tumor and review the world’s literature.


Case report

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CitationEar Nose Throat J. 2012 October;91(10):E22-E25