Primary NK/T-cell lymphoma of the larynx

April 30, 2012
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Laryngeal extranodal non-Hodgkin lymphoma is uncommon, accounting for less than 1% of all laryngeal neoplasms; the B-cell phenotype is predominant. Lymphomas outside the nasal cavity are rare and highly aggressive. We present a case of primary natural killer T-cell (NK/T-cell) lymphoma of the larynx that arose in a 45-year-old man. Because only a limited amount of data is available on laryngeal NK/T-cell lymphoma, the mainstay of treatment remains unclear, although some data suggest that radiotherapy alone is the best option. Our patient was treated with chemotherapy and radiotherapy, and he remained in remission 2 years later.


Primary lymphoma of the larynx is rare, accounting for less than 1% of all primary laryngeal neoplasms.1 Extranodal natural killer T-cell (NK/T-cell) lymphoma, which is extremely rare and highly aggressive, mainly affects the nasopharyngeal area and the nasal cavity; when it occurs in other remote sites, the prognosis is usually unfavorable. Treatment modalities include radiation, chemotherapy, immunotherapy, and a combination thereof.

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