Polymorphous low-grade adenocarcinoma

January 21, 2014
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Pathology Clinic

PLGA affects the palate (60% of cases) most commonly, especially at the mucosal junction of the hard and soft palates; the next most common sites are the cheek and the lip, often the upper lip.

Polymorphous low-grade adenocarcinoma (PLGA) is a low-grade malignant epithelial tumor characterized by an infiltrative growth of cytologically uniform cells arranged in a multitude of architectural patterns. While it is an uncommon tumor, it accounts for about 25% of all intraoral minor salivary gland malignancies. Most patients come to clinical attention between the ages of 50 and 70 years, and the female-to-male ratio is 2:1. PLGA has a predilection for blacks.

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