The author designed a study to assess the healing properties of platelet-rich plasma (PRP) after endoscopic sinus surgery in 30 patients with bilateral and symmetrical chronic rhinosinusitis that was refractory to medical management. At the conclusion of each operation, PRP was introduced into the middle meatus of a randomly chosen side, while the other side was treated normally and served as a control. Patients were followed until both sides healed. After 13 operations, follow-up evaluations demonstrated no benefit to the use of PRP, and the study was terminated early. In general, both sides healed quickly and uneventfully as expected. There appears to be no advantage to the use of PRP in endoscopic sinus surgery.