Ossifying fibromyxoid tumors are rare soft-tissue neoplasms, usually with an indolent course. However, atypical/malignant variants have been described, showing either local recurrence after complete excision or metastasis to the lungs, mediastinum, adrenals, or soft tissue. We report the case of an ossifying fibromyxoid tumor of the left ankle that metastasized to the lung and thyroid gland 12 years after the initial diagnosis and surgical treatment. To our knowledge, this is the first reported case of this neoplasm metastasizing to the thyroid gland.
Ossifying fibromyxoid tumors of soft parts (OFMTs) are rare soft-tissue neoplasms.1 They are usually small, painless, and well circumscribed, and commonly arise in the subcutis or muscle of the extremities; less often, they arise from the trunk or head and neck region.1