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Multiple paragangliomata of the lungs and temporal bone

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November 1, 2008
by Husain A. Sattar, MD, Dorise L. Yang, MD, Aliya N. Husain, MD, Miriam I. Redleaf, MD, and Vijay S. Dayal, MD

Abstract

We report the case of a 71-year-old woman with multiple benign lung paragangliomata and a benign glomus jugulare paraganglioma in one temporal bone that mimicked a malignancy. The patient's lung lesions did not regress with chemotherapy. Subsequent histologic markers suggested several very slowly dividing tumors. We review the patient's medical course and pathology from both sites. A finding of multiple lung paragangliomata should raise the suspicion of a multicentric rather than malignant tumor. Before any chemotherapeutic regimen is initiated, a thorough physical examination of the head and neck should be performed, and biopsy material should be tested for markers of cell division.

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