Malignant melanoma metastatic to the larynx: A case report

January 24, 2013
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Malignant melanoma of the larynx is a rare cancer that can appear as a primary tumor or as a metastasis from a cutaneous head and neck primary. To the best of our knowledge, only 60 cases of primary laryngeal melanoma have been reported in the world literature. Melanomas metastatic to the larynx are even more rare, as only 24 cases have been previously reported. Survival is poor, and recurrence is uncommon. We describe a new case of a malignant melanoma metastatic to the larynx, which represents the first such case in Iran.


Laryngeal malignant melanoma is a rare cancer that presents as both a primary and metastatic lesion.1,2 Primary melanomas of the larynx arise from the intraepithelial melanocytes of normal laryngeal mucosa. These melanocytes are part of the dispersed neuroendocrine cell system, which was previously known as the amine precursor uptake and decarboxylation system.3

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