Amyloidosis: A rare case with nodular lesions on the tongue and buccal mucosa

October 23, 2013
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Head and Neck Clinic

The pathogenesis of amyloidosis appears to be multifactorial, but the common final pathway is identical in all forms of the disease; i.e., the production of amyloid fibrils in the extracellular matrix.

An 82-year-old man was referred for evaluation of nodular lesions on the tongue and left buccal mucosa. He had an 8-year medical history of chronic renal failure and had been treated with hemodialysis. Two months prior to presentation, the first nodular lesion appeared on the tip of his tongue. Seven days later, four new nodular lesions appeared in the oral cavity. The size of the lesions gradually increased.

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