Acantholytic squamous cell carcinoma of the maxilla: Unusual location and aggressive behavior of a rare histologic variant

September 18, 2013
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Acantholytic squamous cell carcinoma (ASCC) of the mucosal membranes has been documented sporadically. The highly aggressive behavior of a mucosal ASCC arising in the oral cavity has been recently reported. To the best of our knowledge, only 1 autopsy case of maxillary ASCC previously has been reported in the literature. We pre-sent what we believe is only the second case of maxillary ASCC. Our goal is to emphasize the aggressive behavior of this tumor in order to add weight to the argument that the prognosis is poor.


Acantholytic squamous cell carcinoma (ASCC) is an uncommon histologic variant of squamous cell carcinoma (SCC).1-3 It generally arises in the sun-exposed skin of the head and neck, although a few sporadic cases in the mucosal membranes have been documented.2,3 In a recent case report, Kerawala suggested that mucosal ASCC is more aggressive than ASCC at other sites.2

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