Bilateral multinodular oncocytomas of the parotid arising in a background of bilateral oncocytic nodular hyperplasia

by Jason Hyde, MD, Masayoshi Takashima, MD, Brennan Dodson, MD, and Sherif Said, MD, PhD | Tuesday, January 01, 2008

IntroductionOncocytic salivary gland tumors are rare, accounting for fewer than 1% of all salivary gland neoplasms.1,2 Although McFarland3 is credited with describing the first oncocytic salivary gland tumor in 1927, pioneering work by Hamperl4 published in 1931 led the way to recognizing oncocytic changes, both hyperplastic and neoplastic. Hamperl's subsequent report of 46 such lesions, which was published in 1962, was the first comprehensive review of oncocytic neoplasms.5Oncocytomas usually present as solitary, and hence unilateral, lesions. To date, only about 20 cases of bilateral tumors have been reported in the world literature.1,6-10 These tumors presented as synchronous or metachronous lesions of the parotid glands to the exclusion of the other major salivary glands.In this article, we report a rare case of synchronous multiple bilateral multinodular parotid oncocytomas that arose in a background of bilateral oncocytic nodular hyperplasia. We also discuss the features that .../continued/

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