Acute dysphonia secondary to vocal fold hemorrhage after vardenafil use

by Vikas Singh, MD, Seth M. Cohen, MD, MPH, Bernard Rousseau, PhD, J. Pieter Noordzij, MD, C. Gaelyn Garrett, MD, and Robert H. Ossoff, DMD, MD | Tuesday, June 01, 2010

IntroductionPhosphodiesterase-5 inhibitors have become an increasingly popular class of medications for the treatment of erectile dysfunction. These medications dilate the penile blood vessels and cause prolonged erections. While these agents are effective in treating impotence, a number of side effects have been reported as a result of their use and misuse. Among these complications are epistaxis, esophageal variceal hemorrhage, intracranial hemorrhage, and hemorrhoidal bleeding.1-5 We report a case of a vocal fold hemorrhage associated with the casual use of vardenafil in a 31-year-old man.Case reportA 31-year-old man, a professional singer, initially presented with a 4-month history of persistent dysphonia, vocal fatigue, and pitch breaks; he reported no acute exacerbations. His medical history was significant for gastroesophageal reflux disease. On examination, he was noted to have pachyderma and a mild fullness of the anterior one-third of the left true vocal fold, but no obvious .../continued/

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